Abstract

Tumor Growth Inhibition by Local Activation of Cellular Sensitivity to Drugs by Focused Acoustic Shock Waves

V.Teslenko (Lavrentyev Institute of Hydrodynamics SD RAS, Novosibirsk, Russia); V.P.Nikolin (Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia); I.V.Mastikhin (International Tomographic Center SD RAS, Novosibirsk, Russia); N.G.Kolosova (Institute of Physiology SD RAMS, Novosibirsk, Russia); V.N.Gorchakov (Institute of Limfology SD RAMS, Novosibirsk, Russia)

e-mail: teslenko@hydro.nsc.ru; vteslenko@mail.ru

Development of methods for efficient delivery of drugs to the cells of certain tissues or organs is given high priority in up-to-date medicine and biology. These methods are of essential importance for chemotherapy and gene therapy of malignancy because they employ organ-targeted delivery of drugs to certain cells. A possible approach to the problem of targeted delivery is a local activation of cell membrane permeability under physical actions. To implement this approach, it is possible to regulate the cell membrane permeability by focused acoustic shock waves (ASW). At present, the methods for focusing ASW that allow localizing the impact within a focal region in a body are developed in much detail. It is shown experimentally that the use of ASW increases considerably the in vivo and in vitro cell membrane permeability and can be used to promote targeted delivery of drugs, including fragments of nucleic acids, to cells.

Section : 5