Abstract |
On Nonlinear Acoustics Methods in
Medical Diagnostics
A.M.Sutin (Stevens Institute of
Technology, Hoboken, and Institute of Applied Physics RAN, Nizhny Novgorod,
Russia); S.Y.Emelianov (Biomedical Engineering Department, University of
Michigan, Ann Arbor, MI, USA); A.M.Tatarinov, A.P.Sarvazyan (Artann Laboratories,
North Brunswick, NJ, USA)
e-mail:
asutin@stevens-tech.edu
In
the last decade, nonlinear acoustics expanded into many area of medical
diagnostics, therapy and surgery. This presentation is aiming at exploring new
medical applications of nonlinear acoustics based approaches. 1. Nonlinear Wave
Modulation Spectroscopy (NWMS): a vibration induced ultrasound modulation
technique is proposed for detection of bone abnormalities and assessment of
bone aging-related changes in bone quality and fracture risk. NWMS sensitivity
to the presence of bone microdamages could be much higher than that of
conventional methods of bone diagnostics. NWMS can reveal subtle changes in
bone microarchitecture. Preliminary in-vitro studies performed on excised bone
samples confirming the feasibility of the proposed approach are presented. 2. A technique based on interaction of
high-frequency focused ultrasound beams with different frequencies is suggested
for remote evaluation of bone mechanical properties closely related to bone
health and quality . 3. A method for
remote non-invasive assessment of the blood pressure was investigated. This
method is based on nonlinear acoustic measurements of resonance frequency of a
homogeneous population of microbubbles. The resonance frequency depends on the
ambient pressure and microbubbles travelling in the blood steam may act as
"microgages" remotely reporting on the variations of local blood
pressure. The nonlinear scattering of ultrasound on microbubbles may serve as
an noninvasive tool for assessing t of vascular system functionality.
Section
: 5